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The Web Application Server Split functionality provides an option to separate the mailstore services mail server and the user interface services web client server.
These servers are running in split mode. Splitting the web client server from the mail server makes the customization process more agile, allowing the roll out of new or updated web UI customization without having to restart the mail servers.
This means zero down time. If you want to customize the Zimbra Web Client or Zimbra Administration Console, you can take the web client server offline and run customization or maintenance, while not having to take down the mail server. The web client server is completely decoupled from mailbox accounts. This means any web client server can service any account request. Zimbra Collaboration includes a configurable backup manager that resides on every Zimbra Collaboration server and performs both backup and restore functions.
You do not have to stop the Zimbra Collaboration server in order to run the backup process. See Backup and Restore. Each Zimbra mailbox server generates redo logs that contain current and archived transactions processed by the message store server since the last incremental backup. When the server is restored, after the backed up files are fully restored, any redo logs in the archive and the current redo log in use are replayed to bring the system to the point before the failure.
A Zimbra Collaboration deployment consists of various third-party components with one or more mailbox servers. Each of the components may generate its own logging output. The following global and server level configuration attributes are available to control and tune the IMAP service. Default value is TRUE. Specifies interface address on which in-process IMAP server should listen; if empty, binds to all interfaces.
Specifies port number on which in-process IMAP server should listen. Default value is The default value of is sufficient to handle up to 10, active IMAP clients.
Specifies port number on which IMAP proxy server should listen. See Zimbra Proxy Components for more information. Specifies maximum size of IMAP request in bytes excluding literal data. By default this value is 10GB. This is a rough limit, because due to internals of Ehcache actual size on disk will often exceed this limit by a modest margin.
Specifies the maximum heap size of the inactive session cache in Bytes before eviction. By default this value is 1 megabyte. This is a rough limit, because due to internals of Ehcache actual size in memory will often exceed this limit by a modest margin. Specifies the maximum amount of disk space the imap active session cache will consume in Bytes before eviction. By default this value is gigabytes.
This is a rough limit, because due to internals of ehcache actual size in memory will often exceed this limit by a modest margin.
LDAP directory services provide a centralized repository for information about users and devices that are authorized to use your Zimbra service. Each server has its own LDAP entry that includes attributes specifying operating parameters. In addition, a global configuration object sets defaults for any server whose entry does not specify every attribute.
A subset of these attributes can be modified through the Zimbra administration console and others through the zmprov commands. LDAP directories are arranged in an hierarchal tree-like structure with two types of branches, the mail branches and the config branch. Mail branches are organized by domain. Entries belong to a domain, such as accounts, groups, aliases, are provisioned under the domain DN in the directory. The config branch contains admin system entries that are not part of a domain.
Config branch entries include system admin accounts, global config, global grants, COS, servers, mime types, and Zimlets. Each type of entry object has certain associated object classes. An LDAP directory entry consists of a collection of attributes and has a globally unique distinguished name dn. The attributes allowed for an entry are determined by the object classes associated with that entry. The values of the object class attributes determine the schema rules the entry must follow.
Other object classes are called auxiliary and may be added to or deleted from the entry. Use of auxiliary object classes in LDAP allows for an object class to be combined with an existing object class. For example, an entry with structural object class inetOrgPerson , and auxiliary object class zimbraAccount , would be an account.
An entry with the structural object class zimbraServer would be a server in the Zimbra system that has one or more Zimbra packages installed. It is designed to coexist with existing directory installations. Represents an account on the Zimbra mailbox server that can be logged into. Account entries are either administrators or user accounts. The object class name is zimbraAccount. This object class extends the zimbraMailRecipient object class.
All accounts have the following properties:. A set of attributes, some of which are user-modifiable preferences and others that are only configurable by administrators.
All user accounts are associated with a domain, so a domain must be created before creating any accounts. Defines the default attributes an account has and what features are allowed or denied. The COS controls features, default preference settings, mailbox quotas, message lifetime, password restrictions, attachment blocking, and server pools for creation of new accounts. Represents an email domain such as example.
A domain must exist before email addressed to users in that domain can be delivered. Also known as mailing lists, are used to send mail to all members of a list by sending a single email to the list address. Are like distribution lists. The difference is members of a dynamic group are dynamically computed by a LDAP search. The LDAP search filter is defined in an attribute on the dynamic group entry.
Represents a particular server in the Zimbra system that has one or more of the Zimbra software packages installed. Attributes describe server configuration information, such as which services are running on the server. Specifies default values for the following objects: server and domain. If the attributes are not set for other objects, the values are inherited from the global settings.
Global configuration values are required and are set during installation as part of the Zimbra core package. These become the default values for the system. Represents an alias of an account, distribution list or a dynamic group. The zimbraAliasTarget attribute points to target entry of this alias entry.
Defines a calendar resource such as conference rooms or equipment that can be selected for a meeting. A calendar resource is an account with additional attributes on the zimbraCalendarResource object class. Represents a persona of a user.
A user can create multiple personas. Represents an external mail source of a user. The data source also contains persona information, including the display name and a link to the signature entry for outgoing email messages sent on behalf of the external account.
A user can create multiple signatures. The authentication method type is set on a per-domain basis. If zimbraAuthMech attribute is not set, the default is to use internal authentication. The zimbraAuthFallbackToLocal attribute can be enabled so that the system falls back to the local authentication if external authentication fails.
The external authentication methods attempt to bind to the specified LDAP server using the supplied user name and password. If this bind succeeds, the connection is closed and the password is considered valid. You can also use the fully qualified host name instead of the port number. If it is an SSL connection, use ldaps: instead of ldap:. The SSL certificate used by the server must be configured as a trusted certificate.
During the authentication process, the user name starts out in the format: user example. In the case of Active Directory, that bind dn might be in a different domain. You can implement a custom authentication to integrate external authentication to your proprietary identity database. When an authentication request comes in, Zimbra checks the designated auth mechanism for the domain. If the auth mechanism is set to custom authentication, Zimbra invokes the registered custom auth handler to authenticate the user.
To set up custom authentication, prepare the domain for the custom auth and register the custom authentication handler. The object has to be an instance of ZimbraCustomAuth or subclasses of it. When an authentication request comes in and the domain is specified to use custom authentication, the authenticating framework invokes the authenticate method on the ZimbraCustomAuth instance passed as the handler parameter to ZimbraCustomAuth.
The account object for the principal to be authenticated and the clear-text password entered by the user are passed to ZimbraCustomAuth. Set the domain attribute zimbraAuthKerberos5Realm to the Kerberos5 realm in which users in this domain are created in the Kerberos database.
The Global Address List GAL is a company directory of users, usually within the organization itself, that is available to all users of the email system.
Zimbra Collaboration uses the company directory to look up user addresses from within the company. The mapping is configured in the zimbraGalLdapAttrMap attribute. GAL is configured on a per-domain basis. Additions, changes and deletions to the GAL attributes are made through the Zimbra Administration Console or from the zmprov commands. Users can modify attributes for their account in the directory.
When users change their options from the Zimbra Web Client, they also modify the attributes when they change their preferences. When you add or change theme skin property files and locale resource files for ZCS on a server, you must flush the cache to make the new content available. When you modify the account, COS, groups, domain, and server attributes, the change is effective immediately on the server to which the modification is done.
On the other servers, the LDAP entries are automatically updated after a period of time if the attributes are cached. The default ZCS setting to update the server is 15 minutes. The caching period is configured on local config key. If you do not specify a name or ID along with the type, all entries in cache for that type are flushed and the cache is reloaded. When you modify global config attributes, the changes are effective immediately on the server to which the modification is done.
On other mailbox servers, you must flush the cache to make the changes available or restart the server. LDAP entries for global config attributes do not expire. Some global config attributes are computed into internal representations only once per server restart.
For efficiency reasons, changes to those attributes are not effective until after a server restart, even after the cache is flushed. Also, some global configuration settings and server settings that are inherited from global config are only read once at server startup, for example port or number of processing threads. Modifying these types of attributes requires a server restart.
To flush the global config cache on all other servers, zmprov flushCache must be issued on all servers, one at a time or use zmprov flushCache -a. Enforce restrictions on which addresses can send to distribution lists and adds Reply-To and X-Zimbra-DL headers to messages sent from distribution lists. Sign outgoing email if it has been configured to do so. The zmconfigd process polls the LDAP directory every two minutes for modifications and updates the Postfix configuration files with the changes.
The Zimbra mailbox server receives the messages from the Zimbra MTA server and passes them through any filters that have been created.
As each mail message arrives, its contents are indexed so that all elements can be searched. ZCS includes a precompiled version of Postfix to route and relay mail and manage attachments. Postfix also plays a role in transferring outbound messages.
Messages composed from the Zimbra Web Client are sent by the Zimbra server through Postfix, including messages sent to other users on the same server. This ensures that the MTA can verify if the user is allowed to relay mail, by checking the associated credentials with the LDAP account. You can enable restrictions so that messages are not accepted by Postfix when non-standard or other disapproved behavior is exhibited by an incoming SMTP client.
These restrictions provide some protection against spam senders. By default, clients that do not greet with a fully qualified domain name are restricted. DNS based restrictions are also available. You can configure Postfix to send nonlocal mail to a different SMTP server, commonly referred to as a relay or smart host.
A common use case for a relay host is when an ISP requires that all your email be relayed through a designated host, or if you have filtering SMTP proxy servers. The relay host setting must not be confused with Web mail MTA setting. Relay host is the MTA to which Postfix relays non-local email. The anti-virus software is configured to put messages that have been identified as having a virus to the virus quarantine mailbox.
You can enable real-time scanning of attachments in outgoing emails sent using the Zimbra Web Client. If enabled, when an attachment is added to an email, it is scanned using ClamAV prior to sending the message.
If ClamAV detects a virus, it will block attaching the file to the message. By default, scanning is configured for a single node installation.
Zimbra uses SpamAssassin to identify unsolicited commercial email spam with learned data stored in either the Berkeley DB database or a MariaDB database. You can also use the Postscreen function to provide additional protection against mail server overload. Both strategies are described in the following topics:. Managing the Spam Assassin Score: SpamAssassin uses predefined rules as well as a Bayes database to score messages with a numerical range.
You can change the spam percentage settings, and the subject prefix at the Administration Console. By default, Zimbra uses the Berkeley DB database for spam training. You can also use a MariaDB database. The SpamAssassin filter learns from messages that users specifically mark as spam by sending them to their junk folder or not spam by removing them from their junk folder.
A copy of these marked messages is sent to the appropriate spam training mailbox. The ZCS spam training tool, zmtrainsa , is configured to automatically retrieve these messages and train the spam filter. The zmtrainsa script empties these mailboxes each day.
Initially, you might want to train the spam filter manually to quickly build a database of spam and non-spam tokens, words, or short character sequences that are commonly found in spam or ham. When zmtrainsa runs, these messages are used to teach the spam filter. Make sure you add a large enough sampling of messages to get accurate scores. To determine whether to mark messages as spam at least known spams and known hams must be identified.
This tool updates SpamAssassin rules from the SA organization. Deliver the email to the recipient. The email is bounced back to the sender. If the sender is not valid, the associated MTA will discard the email i. Setting Up Trusted Networks: The ZCS configuration allows relaying only for the local network, but you can configure trusted networks that are allowed to relay mail. You set the MTA trusted networks as a global setting, but you can configure trusted networks as a server setting.
The server setting overrides the global setting. When using the Administration Console to set up MTA trusted networks on a per server basis, first ensure that MTA trusted networks have been set up as global settings. Continue long lines by starting the next line with space, similar to the following examples:. Enabling a Milter Server: Milter server can be enabled to enforce restrictions on which addresses can send to distribution lists and add Reply-To and X-Zimbra-DL headers to messages sent from distribution lists.
This can be enabled globally or for specific servers from the Administration Console. Use the Administration Console to enable a specific milter server, and to set bind addressing for individual servers.
Zimbra Postscreen is the 8. Its purpose is to keep spambots away from Postfix SMTP server processes, while minimizing overhead for legitimate traffic.
By keeping spambots away, Postscreen frees up SMTP server processes for legitimate clients, and delays the onset of server overload conditions. Zimbra Collaboration Postscreen maintains a temporary white-list for clients that have passed a number of tests. This minimizes the overhead for legitimate mail.
This concept is illustrated in the following diagram, in which undesirable entities are depicted in red; good email candidates are green. Postscreen performs basic checks and denies connection s that are clearly from a bot or zombie.
If the connection is not in the temporary whitelist, Postscreen passes the email to the local Anti-SPAM and Anti-Virus engines, which can either accept it or deny it.
By default, all bots or zombies are rejected. For any Postscreen Attributes that provide the ignore, enforce, or drop instruction, use guidelines as follows:. Allow other tests to complete. Repeat this test with subsequent client connections.
This is the default setting, which is useful for testing and collecting statistics without blocking mail. Go to the zmprov mcf prompt release 8. You can see example usages of these attributes in Enabling Postscreen.
Postscreen 8 searches this list immediately after a remote SMTP client connects. Specify a comma- or whitespace -separated list of commands in upper or lower case or lookup tables. The search stops upon the first command that fires for the client IP address.
During this time, the client IP address is excluded from this test. Specify a non-zero time value an integral value plus an optional one-letter suffix that specifies the time unit. Time units: s seconds , m minutes , h hours , d days , w weeks.
The amount of time allowable between postscreen 8 cache cleanup runs. Cache cleanup increases the load on the cache database and should therefore not be run frequently. Specify a zero interval to disable cache cleanup. After each cache cleanup run, the postscreen 8 daemon logs the number of entries that were retained and dropped.
The amount of time that postscreen 8 is allowed to cache an expired temporary whitelist entry before it is removed. It also prevents the cache from filling up with clients that passed some deep protocol test once and never came back.
This SMTP engine defers or rejects all attempts to deliver mail, therefore there is no need to enforce separate limits on the number of junk commands and error commands.
The filter has the form d. Specify a negative number for whitelisting. To use example. The amount of time allowable for postscreen 8 to use the result from a successful DNS-based reputation test before a client IP address is required to pass that test again.
Specify a negative value to enable this feature. The default is relatively short, because a good client can immediately talk to a real Postfix SMTP server. Enable yes or disable no "non- SMTP command" tests in the postscreen 8 server.
These tests are expensive: a client must disconnect after it passes the test, before it can talk to a real Postfix SMTP server. The default is long because a client must disconnect after it passes the test, before it can talk to a real Postfix SMTP server. The action that postscreen 8 is to take when a remote SMTP client sends multiple commands instead of sending one command and waiting for the server to respond, as either ignore, enforce, or drop.
These tests are expensive: a good client must disconnect after it passes the test, before it can talk to a real Postfix SMTP server. The default is lengthy because a good client must disconnect after it passes the test, before it can talk to a real Postfix SMTP server. Time allowable for a postscreen 8 process to respond to a remote SMTP client command, or to perform a cache operation, before it is terminated by a built-in watchdog timer.
This is a safety mechanism that prevents postscreen 8 from becoming non-responsive due to a bug in Postfix itself or in system software. To avoid false alarms and unnecessary cache corruption this limit cannot be set under 10s.
A list of local postscreen 8 server IP addresses where a non-whitelisted remote SMTP client can obtain postscreen 8 's temporary whitelist status. By default, a client can obtain postscreen 8 's whitelist status on any local postscreen 8 server IP address.
Thus, clients that connect only to backup MX addresses will never become whitelisted, and will never be allowed to talk to a Postfix SMTP server process. The netmask specifies the number of bits in the network part of a host address.
Continue long lines by starting the next line with whitespace. The list is matched left to right, and the search stops on the first match. The maximum amount of time allowable for postscreen 8 to use the result from a successful DNS-based reputation test before a client IP address is required to pass that test again.
Note that the default setting is backwards-compatible with Postscreen versions earlier than 3. The example in this section demonstrates settings appropriate for a global configuration with medium-to-high level Postscreen protection.
Testing uses Postscreen to view results without taking any action. In a testing scenario, you instruct Postscreen to log email connections without taking action on them. Once you are satisfied with the results, you can set Postscreen values to enforce or drop emails, as required. The following real-world example demonstrates return of a error from Postscreen during a test session:.
The Zimbra MTA delivers the incoming and the outgoing mail messages. For outgoing mail, the Zimbra MTA determines the destination of the recipient address. If the destination host is local, the message is passed to the Zimbra server for delivery. If the destination host is a remote mail server, the Zimbra MTA must establish a communication method to transfer the message to the remote host.
For incoming messages, the MTA must be able to accept connection requests from remote mail servers and receive messages for the local users. To receive mail, the MX record must be configured correctly to route messages to the mail server. When the Zimbra MTA receives mail, it routes the mail through a series of queues to manage delivery; incoming, active, deferred, hold, and corrupt.
The incoming message queue holds the new mail that has been received. Each message is identified with a unique file name. Messages are moved to the active queue when there is room. If there are no problems, message move through this queue very quickly.
The active message queue holds messages that are ready to be sent. The MTA sets a limit to the number of messages that can be in the active queue at any one time. From here, messages are moved to and from the anti-virus and anti-spam filters before being delivered to another queue. Messages that cannot be delivered are placed in the deferred queue. The reasons for the delivery failures are documented in a file in the deferred queue.
This queue is scanned frequently to resend the message. If the message cannot be sent after the set number of delivery attempts, the message fails and is bounced back to the original sender. You can choose to send a notification to the sender that the message has been deferred.
The hold message queue keeps mail that could not be processed. Messages stay in this queue until the administrator moves them. No periodic delivery attempts are made for messages in the hold queue. You can monitor the mail queues for delivery problems from the Administration Console.
The Zimbra Proxy package is installed and configured during the Zimbra Collaboration installation. You can install this package on a mailbox server, MTA server, or on its own independent server. When the Zimbra Proxy package is installed, the proxy feature is enabled. In most cases, no modification is necessary. Zimbra Proxy includes the following:.
High performance distributed memory object caching system in which routing information is cached to enable increased performance.
Servelet—located on the ZCS mailbox server—that handles queries for the user account route information. This routing information consists of the server and port number where the user account resides.
Zimbra Collaboration Proxy Route Lookup Handler locates the route information for the account being accessed and returns this to Nginx.
The Memcached component stores the route information for the configured period of time the default is one hour.
Nginx uses this route information instead of querying the Zimbra Collaboration Proxy Route Lookup Handler until the default period of time has expired. The end client behaves as if it is connecting directly to Zimbra Collaboration Mailbox. When Zimbra proxy is configured, the Zimbra proxy config performs keyword substitution as necessary with values from the LDAP configuration and localconfig.
If changes are required after the Zimbra Proxy is set up, modify the Zimbra LDAP attributes or localconfig values and run zmconfigd to generate the updated Zimbra Proxy configuration.
The nginx. In this case you manually identify the location of the Kerberos Keytab file, including Zimbra Proxy password. For example, proxying allows users to enter imap.
The proxy running on imap. If you have any other services running on these ports, turn them off. Zimbra Proxy has the ability to strictly enforce which values are allowed in the Host header passed in by the client.
This is enabled by default on new installations but left disabled for upgrades from previous versions unless toggled during the installation. The functionality may be altered by setting the zimbraReverseProxyStrictServerNameEnabled boolean configuration option followed by restarting the proxy server.
When the strict server name functionality is enabled, additional valid server names may be specified using the zimbraVirtualHostName and zimbraVirtualIPAddress configuration items at the domain level. IMAP proxy is installed with Zimbra Collaboration and set up during installation from the configuration menus. No other configuration is usually required. Use steps in this section if Zimbra proxy is installed with Zimbra Collaboration on the same server.
The connection from users whose mailboxes live on mbs1. If the requesting URL can be examined to determine the user name, then the request is routed to the backend mailbox server of the user in the URL. If the above methods do not work, the IP hash method is used to load balance the requests across the backend mailbox servers which are able to handle the request or do any necessary internal proxying. To set the proxy server mail mode, add the -x option to the command, with the specific mode as either http, https, both, redirect, or mixed.
To set the proxy server mail mode, add the -x option to the command with the specific mode: http , https , both , redirect , mixed. This attribute defaults to TRUE. In an "out of the box" proxy set up, the upstream communication defaults to SSL. For REST URL, you set the host name, service protocol, and services port globally or for a specific domain from the following attributes.
If domain. On a multiserver ZCS, if a load balanced name was needed to create a friendly landing page, a user would always have to be redirected. Now with a full-fledged reverse proxy, users do not need to be redirected. The localconfig variable zimbraMailReferMode is used with nginx reverse proxy. On each proxy node, set the zimbraReverseProxyDefaultRealm server attribute to the realm name corresponding to the proxy server.
For example:. On each proxy node for each of the proxy IP addresses:. The Zimbra Administration Console is a browser-based user interface for the central management of Zimbra servers and user accounts. When you log in to the Administration Console, the tasks you are authorized to perform show up on the Navigation pane. These tasks depend on the rights assigned to your administrator role.
Global Administrators have full privileges to manage servers, global settings, domains, and accounts as well as create other administrators. One global administrator account gets created automatically during software installation. Create additional global administrator accounts anytime later. You can perform administration tasks from the Administration Console or the command line. Delegated Administrators are granted customized administrator roles by the global administrator to manage different tasks from the Administration Console.
See Delegated Administration for more details. At the login screen, enter the complete administrator address - e. From the Administration Console, use the Change Password screen to set the new password string, and to define the policy for user password modifications.
Double click select user account or from the Gear icon, select Change Password from the popup menu. A different login and logout page can be configured either as a global setting or as a domain setting. To specify a URL to redirect administrators to if their login fails authentication, or if their authentication has expired:.
Other configuration and maintenance tasks require the use of the Zimbra CLI because you cannot perform them in the Administration Console. For example: starting and stopping services and managing the local server configuration. At the Administration Console, if you need to view the attribute associated with a particular function, you can click on the text labels of the currently visible configuration page to open the information in a popup.
Guide text is also provided from these popups, as demonstrated in the following illustration. With the attribute popup in view, click More to view guidetext about the field. The organization of the Zimbra Collaboration Administration Console provides quick navigation to the configuration and monitoring tools and views associated with your login privileges. It also provides easy access to various types of Help and the on-screen guide text.
After logging in to the Administration Console, the Home page provides status information and options you can select to navigate to the configuration and viewing options described in this user guide.
The displays and options in the navigation pane and viewing pane change according to your selections. The Gear Icon is displayed with some screens, to enable quick access to functions associated with the functions provided in the screens. For more information about the Gear icon, see Using the Gear icon. The options provided in the Home navigation pane get categorized under the Home directory. Some of the options lead to configuration pages; others lead to pages containing reports, as associated with your selections.
The illustration at right is an expanded view of the options currently supported in the Navigation Pane. The upper bar of the in-view page always displays your current position in the hierarchy, and you can use multiple options for dismissing the current view:.
The Home screen is the default, login view, which provides the Home navigation pane and the Home page. This page provides a snapshot view of system status and a series of quick-access links for essential tasks.
Displays the version of Zimbra Collaboration currently running and in view, and the detected number of servers, account, domains, and classes of service associated with this session. Displays the steps essential to getting started with your Zimbra Collaboration operations, and provides quick links to the functions in this UI:.
Displays the steps you use to establish the domain s to be managed by the Collaborator. Each step is a link to the function in this UI:. Displays the steps for adding accounts for management by the Collaborator. The Monitor screen provides the Monitor navigation pane and the Monitor pages, which display various itemizations about servers monitored by the Collaborator.
The options provided in the Monitor pages provide various methods- dynamic charts, or tables-for viewing the individual or system-wide monitored servers and services listed in the following table. System-wide Information page for Advanced Statistics, which allows you to set up a new monitoring chart using parameters from the selection fields available from this page: Server, Group, Start, end, and Counters.
System-wide Information page, for Message Counts, to examine charts depicting counts over the last 48, 30, 60, and days. The polling intervals for the counts are posted directly beneath each chart. These counts get summarized in periods over the last 48, 30, 60, and days. Access to statistics for a selected Service Host. You can view information for a selected host, as follows:.
Right-click on the Service Hostname and select View from the popup to go to the statistics page for it. You can also double-click on the Service Hostname to access the statistics page. Tab pages from which to view counts of Deferred, Incoming, Active, Held, and Corrupt statistics for detected mail queues.
Each tab page provides summary filtering information and Message details. The Manage screen provides the Manage navigation pane, and the Manage pages, which display the tables categorically provided as Accounts, Aliases, Distribution Lists, and Resources that are currently managed by Collaborator.
Table of Aliases managed by the Collaborator. Each alias is an email address that forwards all email to a specified account. Table of Distribution Lists managed by the Collaborator. A Distribution List is a group of mail addresses contained in a list, with a mail address for the list. When you send a message to a distribution list, you are sending it implicitly to everyone whose address appears in the list. The To: address line displays the distribution list address.
Table of Resources managed by the Collaborator. A Resource is a location or a piece of equipment that supports scheduling for meetings. The Configure screen provides the Configure navigation pane, and the Configure pages, which enable configurations for individual or global components.
Right-click on a table row, or use the Gear icon to access the following functions: New , Delete , Edit , Duplicate. Provides access to tools you use to set various global parameters for your Zimbra Collaboration. Right-click on a table row, or use the Gear icon to access the following functions: Deploy , Undeploy , Toggle Status. Double-click on a table row to access the configuration screens for the selected Admin Extension,.
Right-click on a table row, or use the Gear icon to access the following functions: Deploy , Undeploy. Double-click on a table row to access the General Information screen for the selected certificate,. Right-click on a table row, or use the Gear icon to access the following functions: Install Certificate , View Certificate. Right-click on a table row, or use the Gear icon to access the following function: View.
Right-click on a table row, or use the Gear icon to access the following functions: Add , Delete , Edit. Global Settings define the default global values for servers, accounts, COS, and domains. These default values and parameters apply when no specific values and parameters for particular items are in their settings.
You configure the defaults for Global Settings during installation. You can change the settings at any time from Global Settings at the Administration Console. Configure the number of threads that can be used to get the content from the remote data sources.
For more information, see General Information Configuration. Set anti-spam and anti-virus rules. Changes to the Spam-check settings do not take effect until the server restarts. Changes to the theme settings require flushing of the server theme cache by using Flush Cache on the toolbar in Server settings.
Configure the company name to be displayed in the prompt on the Authentication Required dialog used to log in to Briefcase folders shared with external guests.
Set up a retention and deletion time threshold for items in user folders. You can configure retention and deletion policies as a global setting, or configure COS-level policies instead of inheriting from the global settings. Set parameters for Web Proxy and Mail Proxy. There are also tools provided for setting Advanced Proxy parameters. Users retrieve private keys from LDAP servers. Set parameters for backup-for standard or auto- grouped mode.
For more information see Backup and Restore. Administrators can access and download specific wizards and tools from this page. Access Zimbra utilities, which provides downloadable zip packages - for general administration use, and to synchronize an individual end-user - containing migration wizards for various platforms, and Outlook connectors.
Additional information is provided in Downloadable Wizards and Connectors. Find out if your system needs a Zimbra Server update or not, and use this page to view polling and email contact information pertinent to software updates for your system.
View tabular details about account migrations, as detected by your system. This page lists total imports and the status of each. This page also provides the name s of the owners for each account migration listed. See also Migrating Accounts from a Zimbra Server. Use this page to browse for the latest version of software to be uploaded to your system. After selecting the image, you can use Upload on this page to complete the software upload.
Access a summary view of current free and total space MB based on the most recent system backup. You can also choose an administrator from this navigation pane to view their backup history. The history lists labels, start and end times, and success or failure for each backup occurrence.
Each of these listings is associated with an identical displayed directory path to the backup target. The section Backup and Restore provides additional information. Use the Tools and Migration screen Downloads option to get the tools described in this section. Get zip files to perform a server-to-server migration of mail, calendar, and contacts from Microsoft Exchange or PST file to the Zimbra Collaboration Server. The server name, port, and other variables particular to an organization can be customized.
Customization replaces all instances of the Zimbra product name and logo. The Search screen displays the Search results from queries made in the Search field in the Administration Console header. When you open this page without entering a search query, All Results is the default search, which displays accounts, domains, and distribution lists in the Content pane.
The auto-completion function allows you to enter a partial name, then select a searchable name from the displayed list of matched strings. You can also use the Zimbra mailbox ID number to search for an account.
However, to return a search from a mailbox ID, the complete ID string must be entered in the search. Search for a user by first name, last name, display name, or account ID number. You can search for administrators or delegated administrators only. Search for accounts by the last login time. You can specify a date range to search. By default, this section includes predefined common search queries.
You can also create and save your queries. After you enter the query syntax, click Save Search and provide a name for the search. The search is then added to this Saved Searches section. At the Search field, use search options from the drop-down selector to define the type of search, as either accounts , distribution lists , aliases , resources , domains , class of service , or all objects.
Partial entries are allowed as search criteria, but a search based on mailbox ID must include the complete ID string. The Help Center is a reference of resources available from the online help and documentation, which you can access with the links provided in the Help Center screen. Use this page, also, to access community forums and to view expert responses to the top migration questions. The selection of a category from the Navigation pane typically results in a tabular display of all managed objects for the selected category.
All tables display labeled columns in which to view information such as email addresses, display names, status, last logins, and descriptions if configured. Each row in a table enables actions you can perform if you require additional information or access to the configuration for the selected table entry. Display ID details for the selection, similar to the example at right invoked from an Accounts row.
Access the popup menu for a selected table row. The popup menus from a typical table may differ from row to row, as demonstrated in the following examples. Global administrators can create the message- or messages-of-the-day MOTD that administrators view when logging into the Administration Console. The MOTD displays during administrative login at the top-left of the Administration Console, similar to the example below. To remove a message from view, click Close located alongside the message content.
Use the zimbraAdminConsoleLoginMessage attribute, with guidelines in this section, to create a single message of the day, or to create multiple messages to be displayed. Use the zimbraAdminConsoleLoginMessage attribute, with guidelines in this section, to delete a single message of the day, or to delete multiple messages. Place a minus sign - before the attribute, and double quote marks at the beginning and end of an individual message-id for deletion.
This section provides birds-eye views of the functions you can use when navigating the Administration Console, in the following topics:. You can select options to perform on a selected entity from the navigation pane from the Gear icon or a topical popup menu.
The Gear icon is always located at the upper-right edge of the page view if pertinent to selectable items in the displayed page. The following example demonstrates Gear options based on the selection of a navigation bar topic, versus a table row entry from within the same page view. The following table provides a high-level view of the operations derived from the Gear icon, which varies for particular functions.
The following example demonstrates the popup options provided by a specific selection in the page view. The Administration Console logically groups a wide range of Configuration options into containers. Applicable configuration options inside these containers are listed in the High-level View of Administration Console UI.
By default, all containers on a page are opened expanded. Choose a log detail level. Support may request logs when you require assistance. We recommend that you set the log level to Verbose while becoming familiar with the tool. An administrator creates the account for you on the Zimbra Collaboration Server and gives you the migration tool application and the following information which you need to migrate your PST files.
The port number used by the server is usually 80 for non-secure connections and for secure connections. Filters : Choose below filter options to skip unwanted PST items during migration. Migrate On or After : This option filters out messages from before the provided date. The tool skips the migration of messages before this date. Maximum message size : The message size includes the message and attachments. Leave the field blank to use the Zimbra Collaboration server setting for maximum message size.
If you set a value here, this value cannot be larger than the global MTA setting for the maximum size of a message. The default maximum message size is 0 indicating no size limit.
Click Save to save configuration information in a file which can be loaded later using the Load button on the Source Information page when you next run the migration tool. In the Results dialog, view the migration status of the PST file, including progress, errors, and warnings.
To view the results log, double click your account. A new tab opens and displays the account log information. This shows the migration status. The progress bar shows the state of the migration, accompanied by status messages.
Double-click your account name in Accounts, and an individual tab shows folder-by-folder migration status, along with folder-by-folder bottleneck statistics mentioned above. Click X on the appropriate tab to close view. Each migration generates several log files. Click Stop to stop the migration. To restart, go back to the previous view, and click the Migrate button. Once done, click Save to save the above configurations as an XML file.
The ZCS components are configured during the initial installation of the software. After the installation, you can manage the following components from either the Administration Console or using the CLI utility.
Help is available from the Administration Console about how to perform tasks from the Administration Console. Global Settings apply to all accounts in the Zimbra servers. They are initially set during installation. You can modify the settings from the Administration Console. Configurations set in Global Settings define inherited default values for the following objects: server, account, COS, and domain.
If these attributes are set in the server, the server settings override the global settings. Configuration of company name display for external guest log on, when viewing a shared Briefcase folder.
View of current Zimbra license information, license updating, and view the number of accounts created. Use the General Information screen to view and set global parameters for servers that have been installed and enabled. The maximum number of GAL results returned from a user search.
This value can be set by domain: the domain setting overrides the global setting. Number of threads used to fetch content from remote data sources. The duration of time that the server should "rest" between purging mailboxes. If the message purge schedule is set to 0, messages are not purged, even if the mail, trash and spam message life time is set.
Global email attachment settings allow you to specify global rules for handling attachments to an email message.
You can also set rules by COS and for individual accounts. When attachment settings are configured in Global Settings, the global rule takes precedence over COS and Account settings. See Blocking Email Attachments by File type for information about this section of the screen. Users cannot view any attachments. This global setting can be set to prevent a virus outbreak from attachments, as no mail attachments can be opened.
Email attachments can only be viewed in HTML. This global setting states the COS sets the rules for how email attachments are viewed.
You can also reject messages with certain types of files attached. You select which file types are unauthorized from the Common extensions list. You can also add other extension types to the list. Messages with those type of files attached are rejected.
By default the recipient and the sender are notified that the message was blocked. If you do not want to send a notification to the recipient when messages are blocked, you can disable this option. Use options from the MTA page to enable or disable authentication and configure a relay hostname, the maximum message size, enable DNS lookup, protocol checks, and DNS checks.
The MTA that the web server connects to for sending mail. The default port number is The Relay MTA for external delivery is the relay host name. If this attribute is not set, the domain MX setting is checked against zimbraSmtpHostname.
MTA Trusted Networks. Configure trusted networks that are allowed to relay mail. If this option is disabled, set a relay host in the Relay MTA for external delivery. If Allow domain administrators to check MX records from Administration Console is checked, domain administrators can check the MX records for their domain.
If Enable Milter Server is checked, the milter enforces the rules that are set up for who can send email to a distribution list. Set the Maximum messages size for a message and its attachments that can be sent. You can enable the X-Originating-IP header to messages checkbox. The X-Originating-IP header information specifies the original sending IP of the email message the server is forwarding. With POP3, users can retrieve their mail stored on the Zimbra server and download new mail to their computer.
One domain is identified during the installation process. You can add domains after installation. From the Administration Console you can manage the following domain features. A domain can be renamed and all account, distribution list, alias and resource addresses are changed to the new domain name.
Bio-Check UK is dedicated to meeting those ever-growing needs and demands of our customers. We guarantee the quality of the products and services we provide, more mindful than ever of the increasing pressure on our food producers and the laboratory services on which they depend.
Bio-Check's Quality Management System is IS0 approved for development and manufacture of test kits for the detection of contaminants and adulterants in food products. Bio-Check UK founder Phil Goodwin and his team have many decades of experience in the field of in vitro diagnostic testing for medical diagnostics and research, pharmaceutical analysis and food testing applications.
They have been responsible for the commercialisation of many immunoassays and other diagnostic techniques, including food allergy diagnostics, detection of allergens, wheat gluten, mycotoxins and meat species adulteration detection in food.
If you share this aim and are interested in our laboratory and on-site test kits, analytical services, training and pre-audit consultancy services we would like to speak to you. Bodycote Health Sciences Birmingham, UK Bodycote Health Sciences offers analytical chemistry, bath release testing, biological analysis, microbiological testing, and material testing.
Our technologically-advanced facility is based in Nottingham, in the heart of the UK. Storing over , samples from over 70 different countries, we are well practised in the requirements and processes needed to store a wide array of biological samples from across the world.
Our facility provides storage for samples at a range of different temperatures; degrees, degrees and degrees liquid nitrogen. Our samples include purified stem cells, human tissue, whole blood, clinical specimens and biological solutions. We are also one of the only cryogenic storage facilities to boast a fully-operational clean room, a facility which enables the production of live cell cultures. Biorelate Unit 9, Williams House, Manchester Science Park, Manchester, M15 6SE United Kingdom Biorelate was founded in from cutting-edge scientific research into how biomedical curation can utilise existing dark knowledge to accelerate future drug discovery.
Based on the data we estimate and rank in-vivo properties of the compounds based on published and validated models. We offer consultancy to setup these measurements and we are offering developing new local models based on the client's compounds data.
Our mission is to code cells for health. To do so, we apply the principles of computation to biology. Our current focus is to develop a scalable technology platform capable of producing consistent batches of every human cell. This has the potential to unlock a new generation of medicine: it will enable research and drug discovery to move on from inappropriate models and work with the cells that actually are affected by human disease.
A scalable platform of consistent cells will also be the basis for a new generation of cell and tissue therapies. Human stem cells, within days, convert into consistent, mature, functional cell types providing a high quality human model. Applications: — Academic research — Drug development — Neurotoxicology — High-throughput screening — Genetic screening e.
CRISPR screening — 3D bioprinting - Neuromuscular junctions - Metabolism Research Batch to batch reproducibility and homogeneity create a stable human model that is ready for experimentation as early as 2 days post revival.
Industrial scale quantities at a price point that allows the cells to be used from research to screening scale. Cells arrive programmed to rapidly mature upon revival.
Easy to use, only one medium required in a simple two-step protocol. Our drug discovery services include de novo assay development, target analysis and bespoke screening strategies, compound screening, medicinal and synthetic chemistry, computational chemistry and compound management, all with access to a library of K lead-like compounds via Compound Cloud.
Our team of expert scientists has experience of successfully working from assay development through to preclinical and clinical candidates across all biological target classes and major therapeutic indications. As part of its compound management service, BioAscent currently holds and manages over 1 million compounds for our customers, in both liquid and solid formats.
Through the Compound Cloud service, the company provides rapid access to an IP-free library of approximately , lead like compounds in screening-ready format. With these instruments the Centre can help identify and quantitate a wide range of analytes.
The Centre allows users to run their own samples on the instruments after training which can reduce their analysis costs and allow them to keep control of their work. We look forward to serving your research needs and becoming your long term research partner. Biognosis Hailsham, England United Kingdom Biognosis specialises in the supply of quality kits and reagents for the diagnosis of human and veterinary diseases.
Our products are sourced from around the world and currently totals over , kits. Over the past 50 years, BBI has grown from a small specialist company, to a global business with manufacturing sites in five different countries, spanning three continents.
Innovative new projects include the integration of emerging technologies into our products, such as the Novarum Smartphone Reader. Express Scripts acquired Medco Health Solutions in In August , Bracket became an independent portfolio company of Parthenon Capital Partners, a Boston- and San Francisco-based growth-oriented private equity firm that provides capital and strategic resources to growing middle market companies for acquisitions and internal growth.
Together, Bracket and Parthenon Capital Partners are committed to continued innovation and growth, and to providing exceptional service to our pharma, biotech and medical device industry clients. Through our ongoing research and development synergy we are bringing to market unique and competitive products and services to accelerate research in stem cells, human tissues and 3D cell culture.
Read more about our hospitals. The objective of UCLPartners is to translate cutting edge research and innovation into measurable health gain for patients and populations through partnership across settings and sectors, and through excellence in education. To achieve this goal, we encourage interaction between users and lab members of the core facility.
Support and training is provided for the use of all analysers, help is provided in experiment design, data interpretation, presentation and troubleshooting. A full sorting service is also provided. Bioprogress Technology England United Kingdom BioProgress Technology offers an array of enabling systems for the food, medical and pharmaceutical industries. Samples include live cells from bone marrow, plasma from peripheral blood and CSF.
The Bank also holds a collection of HLA typed cord blood. The Bloodwise CellBank is comprised of samples donated by children diagnosed with leukaemia in the UK.
These samples are available for use in research into childhood leukaemia. UK-based researchers can apply to use samples from CellBank for peer-reviewed and fully-costed research projects.
BioClavis Ltd. TempO-Seq is a high-throughput assay specifically designed for very efficient profiling of molecular signatures or transcriptomes from limited sample amounts including FFPE sections, tissue microarrays, or fine needle aspirates.
Importantly, due to the lack of purification and reverse transcription steps, TempO-Seq excels where traditional techniques fail: low input, RNA degradation, or formalin fixation have negligible impact on performance. Data is delivered in a standard format compatible with essentially any secondary analysis pipelines such as CMap or BMDExpress, and we offer bioinformatics support to help you make sense of the data.
TempO-Seq therefore enables efficient, sensitive, and inexpensive profiling of both in vitro and in vivo samples or patient cohorts at a large scale, and BioClavis can work with you to implement molecular endpoints in your high-throughput studies.
It is a collection of well-characterised, validated clinical material including tissue tumour and normal in a variety of formats, blood, cells and other derivatives, matched with clinical information.
BioPark Broadwater Road Welwyn Garden City, England United Kingdom Located close to the heart of London's biomedical technology community, BioPark provides specialist facilities and support for bioscience and health technology businesses, encouraging growth and the development of new products and technologies.
Binding Site 8 Calthorpe Road Edgbaston, Birmingham B15 1QT United Kingdom Binding Site is a Specialist Protein company committed to the research, development, manufacture and distribution of innovative immunodiagnostic assays for the global laboratory market.
Contract Chemicals Knowsley, England United Kingdom Contract Chemicals offers liquids and solid handling, waste treatment, analytical facilities, and compound production. Cambridge Discovery Chemistry The Merrifield Centre Rosemary Lane Cambridge CB1 3LQ Cambridge Discovery Chemistry provides innovative chemistry services to accelerate discovery and process research, serving the pharmaceutical, agrochemical and biotechnology industries.
Cropnosis Ltd. As part of Wood Mackenzie, we introduced our first product, the Agrochemical Service, in The Service went on to become the foremost source of data and analyses on the global agrochemical industry.
Since the middle of the s, the Service has also covered the commercial aspects of the rapidly expanding agricultural biotechnology sector. In , we expanded our offerings with the introduction of a suite of databases, which complement the Service by offering a detailed sales breakdown on all aspects of the crop protection market. We also provide a range of strategic consultancy services, utilising our deep foundation of knowledge to offer advice to the industry and associated organisations.
The Cropnosis business has had a varied history under the ownership of Wood Mackenzie. In , the business, together with the Equities division, was sold to Bankers Trust International. Banker's Trust was in turn acquired by Deutsche Bank in At the end of , Wood Mackenzie regained its independence via an employee buyout.
As an extension of this, the crop protection division was bought by its staff on 1st August and transferred to an independent company named Cropnosis. As a totally independent company, focussed only on crop protection and biotechnology, Cropnosis is more able to service changing industry needs.
At the same time, we aim to maintain the market leadership and high standard of quality for which we are renowned. We have a team of experienced and qualified scientists who can understand your needs and deliver innovative and practical solutions.
CambCol Laboratories is a new venture, that was established to transfer the peptide synthesis facility and related interests of the Farndale Lab in Biochemistry at the University of Cambridge into a new, commercial entity. The core business of CambCol Laboratories is the synthesis and distribution of collagen-like, triple helical peptides and platelet-related materials. CellAura Technologies Nottingham, UK CellAura Technologies provides microscopy, fluorescent ligand binding, screening services, fluorescence-based services, and dual readout binding and function.
Progressive healthcare education and patient care are successfully integrated with our research facilities in this major teaching and research centre. Our academic and clinical staff are recognised as being world-leading experts in their fields.
They provide valuable clinical services to the people of Wales in addition to their academic responsibilities. It uses its NMR-based technology to accurately solve the bioactive three-dimensional structures of molecules independently of techniques such as X-ray crystallography and computational chemistry. As well as working in partnership with the pharmaceutical industry, C4X Discovery is applying its technology to high-value therapeutic targets to generate proprietary drug candidates and intellectual property.
Carbone scientific provides fine chemicals, pharmaceutical intermediates, and active pharmaceutical ingredients to the global marketplaces. Our aim is to make those most popular products available to these pharmaceutical and biotech companies, research organizations and university labs worldwide.
Our online catalogue has already listed over 50, products and over products in stock. Any customers could be easily to select any products from our online catalogue for creating purchase orders.
The very competitive price and lead time information are available for you after you register at our web site. Haemato-oncology samples are stored at presentation and throughout the disease course, including at remission and relapse. In addition CEHRB stores haemato-oncology and oncology samples which are specifically taken for the biobank, usually in response to a specific project.
Our facility within Manchester Medical School is capable of processing hundreds of biological samples each day for storage or for immediate analysis. We process a range of sample types including blood, urine, sputum, synovial fluid and saliva. We are experienced in conducting large sample collection projects for genetic epidemiology experiments such as GWAS, deep sequencing, candidate gene analysis, proteomic, transcriptomic and metabolomic experiments.
CIGMR Biobank supports a number of Manchester-led collaborative research projects requiring large numbers of biological samples for analysis e. The Biobank also manages sample collections for a number of nationally important collections e. This collection contains the largest number of biological samples gifted by people with MND for research in the UK.
For a list of the collections we manage and facilitate please click here. Cole-Parmer Hanwell, London, UK Cole-Parmer offers laboratory and industrial fluid handling products, instrumentation, equipment, and supplies. Since our establishment in we continue to grow our research in terms of revenue, national and international reputation and scientific excellence. We service all sectors of the fresh produce supply chain including many of the major multinational food companies, multiple food retailers and undertake research for both national and international Governments, research councils, multinationals and various grower levy bodies.
Key research areas Fundamental postharvest physiology and biochemistry of fresh produce Targeted and non-targeted metabolomics Technology development for reducing waste and extending storage, shelf- and home-life of fresh produce Sensor and product development including packaging.
Chemivate Unit 5 Canal Terrace Worksop, Nottinghamshire S80 2DF United Kingdom Chemivate offers innovative and diverse chemical compound libraries for sale to pharmaceutical and biotechnology companies for lead discovery.
Chemivate also offers services to support the optimisation and development of these compounds into drug candidates. Our assays support our clients in candidate selection, medium-throughput screening, differentiation, mechanism of action, target discovery and proof of concept studies.
Our technologies include multi-colour flow cytometry, multiplex cytokine analysis, multiplex quantitative immunohistochemistry, immuno-fluorescence microscopy, phenotypic screen deconvolution, quantitative image analysis, qPCR, RNAseq, and electrophysiology. We are an international multi-disciplinary consultancy based in Tormarton near Bristol, England , with representation in the US.
We are a networking business, well-integrated in the various policy and practice groups within our chosen business areas, and enjoy a close working relationship with our industrial clients. The company began as a one man operation in As a result of our successes, the company continues to grow and expand its resources.
We currently have over 12 members of staff. Of these, six work solely on chemicals regulation including REACH, two work on sustainability and environmental services, and the rest support both.
We have a clear policy of only growing by the direct employment of like-minded, committed people. Our People explains who we are and our specific areas of expertise. We take our inspiration from Caleb, a character in the Old Testament, who had the foresight to see that the Promised Land was within easy reach 40 years before his compatriots. They were not able to overcome their fear of the unknown, coupled with their anxiety about change, and suffered unnecessarily for 40 years as a consequence.
The future is in the hands of those who face up to the present realities. Engage our experienced scientists to work alongside your chemists to solve problems, provide fresh ideas, remove roadblocks and add direction and insight, and reach your next milestone faster and more cost effectively.
Computational chemistry helps your chemists understand as much as possible about the systems they are working on. This makes it easier to direct your resources in the direction most likely to succeed, saving you time and money. Every client brings a different approach, new science and a fresh way of working. We propose methods that provide answers in the most intelligent and innovative way we can.
Collaboration often sparks new and better methods and ideas, through new challenges and by the synergistic nature of contract research. We have extensive industry experience and a proven track record working on over projects with many leading pharmaceutical, biotech, agrochemical, flavor and fragrance companies. As our services are flexible, you can accessing expertise where and when you need it you eliminate unnecessary overheads while obtaining a world class service.
Use us as your long term CRO or to help navigate bottlenecks in your project. Cranfield University - Applied Mycology and Predictive Microbiology Core Cranfield Bedfordshire MK43 0AL United Kingdom The mission of the Applied Mycology and Predictive Microbiology Group is to understand the effect of environmental factors on the physiology of economically important microbes, particularly fungi, and to exploit these understandings for the food, environment and health sectors.
Chiltern International offers clinical development, biometrics, and pharmacology for the central nervous system, oncology, opthalmology, and pediatrics. Due to growing demand across an increasing range of service offerings and geographies, Costello medical has grown organically since foundation in to a team of over based in Cambridge, London, Manchester, Boston US and Singapore.
Alongside our widening technical and creative capabilities, we remain committed to our core values of high quality scientific work coupled with exceptional customer service at competitive and transparent prices. Out talented team has experience with a variety of leading pharmaceutical companies and a track record of success in a broad range of disease areas.
Chiral Quest Cambridge, UK Chiral Quest offers custom synthesis, process development, intermediates, custom synthesis, and chiral products. The partners and associates have an in-depth knowledge of the pharmaceuticals, medical biotechnology and medical technology industries.
Chiralabs Kidlington, Oxfordshire, UK Chiralabs provides contract expert chemical, biochemical, spectroscopic and physical analysis services and undertakes investigative, problem-solving studies of substances and products in a wide range of fields, including for the consumer, pharmaceutical, biopharmaceutical, biotechnology, health, nutrition, food, plastics, chemical, engineering and waste industries.
We frequently investigate "unusual" or "unknown" materials. As well as routine analysis, we perform complex, multi-faceted investigations of challenging problems. We are world-leading experts in chirality, circular dichroism, optical spectroscopies, crystallization, biopharmaceutical structure and multi-technique analysis.
Where required, we develop new approaches to solve problems. Charles River Laboratories Robinson Building Little Chesterford, England, CB10 1XL United Kingdom Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts.
Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www. Charles River Laboratories Elphinstone Research Centre Elphinstone, Scotland, EH33 2NE United Kingdom Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts.
Charles River Laboratories Martingale Way BS20 7AW United Kingdom Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. We specialise in chromatography method development and validation services, personalised to you and your business with a flexible approach.
Ceram Stoke-on-Trent, England United Kingdom Ceram is a world leader in developing bioglasses and bioceramics for use as carriers for a variety of active ingredients in addition to offering chemical analysis, material analysis, and environmental analysis, and product testing services.
Ceram Queens Road Penkhull Stoke-on-Trent, Staffordshire ST4 7LQ United Kingdom Ceram is a world leader in developing bioglasses and bioceramics for use as carriers for a variety of active ingredients in addition to offering chemical analysis, material analysis, and environmental analysis, and product testing services.
Our technologies enable novel insights for research as well as fresh approaches to treating disease. We work on demand with pharmaceutical, medical device and medical diagnostics companies through a personalized approach. We offer several services including our award-winning Doctors Speaking With Doctors.
See our service offer at www. Concept Life Sciences 2 James Lindsay Place Dundee Technopole Dundee, DD1 5JJ United Kingdom Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors.
We also work closely with academic groups. Formed in , our business has expanded through a mix of organic growth and targeted acquisition. Today, we are home to more than employees, working from 7 sites across the UK, sharing a common focus on problem solving, quality, collaboration, communication and flexibility. By bringing together teams of highly trained scientists, excellent laboratory facilities and an in-depth understanding of our core markets, we have created a business that is greater than the sum of its parts.
This synergy means we have the in-house resources to offer a range of integrated services to our clients. Our operations are structured around two divisions. Our Integrated Discovery and Development Services division supports discovery and development in the pharmaceutical, biotechnology, agrochemical, chemical and consumer industries.
Our Analytical Services division provides an extensive range of integrated services to clients in the life sciences, food, industrial and environmental sectors. Following our acquisition of Aquila BioMedical in we are pleased to now support specialist research in immunology, immuno-oncology, neurodegeneration, fibrosis, regenerative medicine, histology and GCP analysis.
Concept Life Sciences Discovery House Discovery Park, Ramsgate Road Sandwich , CT13 9ND United Kingdom Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors.
Concept Life Sciences Frith Knoll Road High Peak England, SK23 0PG United Kingdom Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors.
Concept Life Sciences Alderley Road Alderley Edge Alderley Edge, England, SK10 4TG United Kingdom Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors.
Concept Life Sciences 20 Campus Road England, BD7 1HR United Kingdom Concept Life Sciences is a knowledge-based, science-led business providing a wide range of innovative and integrated solutions to clients in the pharmaceutical, biotechnology, food, environmental, agrochemical, petrochemical, chemical and consumer products sectors.
CEA are specialists in regulatory environmental risk assessments for chemicals, toxicology and REACH compliance, providing strategic support for product registrations across Europe. In the pesticidal products area, CEA undertakes data evaluation, the preparation of risk assessments and regulatory documentation dossier segments , including project management and co-ordination of work packages.
In addition, CEA offer bespoke higher tier aquatic mesocosms and laboratory studies and higher tier environmental fate studies, according to GLP. The compliance team also provides support in toxicology, ecotoxicology, exposure assessments, chemical safety reports, dossier preparation, substance identity confirmation and preparation of Safety Data Sheets.
We also have extensive experience of non-standard toxicology and ecotoxicology studies, and modelling of substances in the environment. Services: bespoke protein expression, inhibition screening. Cypex provides metabolite synthesis, protein expression, CYP inhibition screening, recombinant cytochrome Ps bactosomes , and research products.
All the samples have appropriate authorisation and ethical approval for storage in the bank and for use in research. Custom Pharmaceuticals Hove, England United Kingdom Custom Pharmaceuticals offers packing, gateway testing, regulatory services, product development, clinical trials manufacture and packing and analytical development services.
The facility features environment simulation tools, which provide a world-class resource for the detailed study of soil-implement, soil-human and soil-plant-water interactions and the optimisation of machinery efficiency, performance testing and method development.
ChemOvation ChemOvation Ltd. CWF has invested heavily in production and technology facilities over the last two decades and now have a highly efficient bottling capability. CWF has eight packaging lines including dedicated lines for wine There is high volume fermentation capacity, stainless steel temperature controlled bulk wine storage available.
CWF uses traditional British winemaking practices such as Flor fermentation. Bulk wines have been bottled in CWF was also the first packer in the UK to introduce a nitrogen flush facility to reduce oxygen contamination in bag-in-box products. CWF are the leading contract packer in the UK for customer exclusive label alcoholic ready to drinks.
Glass filling options include Cranfield University - Cranfield University Experimental Farm Cranfield Bedfordshire MK43 0AL United Kingdom Cranfield University is recognised internationally for its work in relation to soil and water management and the interface between agriculture and the environment. This is underpinned by our specialist expertise and a range of laboratory and field research facilities.
Largest of these is the Cranfield University Experimental Farm. This is a commercially run farm which is also used for field scientific and engineering research. Located at Silsoe, Bedfordshire, the Cranfield University Experimental Farm comprises hectares of arable land with a number of small farm woods and a mature agro-forestry trial site.
Draining to either groundwater or local surface waters, the farm covers several different soil types, slope conditions and cropping histories that offer opportunities for replicated plot experiments, as well as field and subcatchment scale studies.
Research work includes: 1. Soil and water engineering and management soil mechanics and dynamics, on-the-go sensors to monitor soil properties, soil remediation, soil degradation, soil-plant-water interactions, nutrient management, hydraulics, tillage and cultivations 2. Field and environmental engineering irrigation and drainage, soil conservation, soil injection and land application of biosolids, controlled traffic farming systems, water well pumping technologies, irrigation studies and off-road vehicle capability 3.
Agricultural mechanisation precision seeding and weeding, variable input agriculture, harvest machinery, crop processing machinery, precision drills and tillage equipment Activities on the farm are supported by a fully dedicated Land Equipment Centre and workshops, with a range of tractor units, farm machinery and agricultural implements. The farm is used by Cranfield staff as a valuable research, training and teaching resource.
Cranfield University - Volatiles Analytical Laboratory Cranfield Bedfordshire MK43 0AL United Kingdom A state-of-the-art analytical facility to determine concentrations of organic compounds in vapour phase in media such as soil gas, ambient and indoor air.
Field instrumentation such as photoionisation detectors PID and air sampling pumps is available for site investigations. Our passive and pumped sorbent tube sampling technology enables determination of ppb concentrations of a wide range of organic chemicals in air.
Our experienced staff have applied technology to studies of contaminated land, occupational, ambient and indoor air quality and applied data to the assessment of risk of exposure and consequential human health effects.
We proudly serve customers across the globe delivering projects from lead optimisation through to product launch and life-cycle management. As an independent, scientifically-unbiased and commercially-minded CRO, CatSci is dedicated to understanding and optimising your chemical reactions and manufacturing processes. Favouring a consultative approach, we take the time to understand your project objectives to design and deliver tailored solutions to match your specific demands.
Our large pharma pedigree and extensive experience working on small molecule drug discovery and development projects mean that we can expedite your candidate selection, route design, process scale-up and optimisation. Through these companies we offer life science reagents, services and instruments.
Products include reagents, cells, human samples and more. Services include antibody development, peptide synthesis, bulk manufacture, humanization and more.
Crown Bioscience, Inc. We develop world-leading preclinical efficacy models and provide both in vitro and in vivo testing services and preclinical research products. Cytome Technologies Upper Heyford, England, OX25 United Kingdom Cytome Technologies is a contract research organisation specialising in characterisation of the immunoproteome using bioanalytical, biophysical and cell biology assays.
We provide assay and custom assay development services to pharmaceutical and biotechnology clients. Cantab Biopharmaceuticals Cambridge, England United Kingdom Cantab Biopharmaceuticals is focused on the development of "biosuperior" products with extensive experience in biopharmaceutical discovery, process development and GMP manufacturing.
ChemPharmaServe Cambridge, England United Kingdom ChemPharmaServe provides innovative solutions to pharmaceuticals and biotechs to help fast tracking their drug discovery and developmental projects by making novel molecules they need.
ChemPharmaServe 14 Cundel Dr. Cambridge CB24 8RU UK ChemPharmaServe provides innovative solutions to pharmaceuticals and biotechs to help fast tracking their drug discovery and developmental projects by making novel molecules they need. We provide crystal and particle engineering solutions to the pharmaceutical and biopharmaceutical industries, contributing to human health by enabling new and more effective therapies.
Crystec SCF technology can be applied to small and large drug molecules in a range of dosage forms. Our services include crystal form screening and particle design including composite particles and co-crystals , addressing issues of poor solubility and stability, improved delivery, and product enhancement in support of lifecycle management.
Our process is scaled to GMP manufacturing levels. We are also engaged in in-house programmes to develop improved products and currently have licensing opportunities available in several therapeutic areas, including urge incontinence, fungal infections, and malaria.
The first product based on SCF technology is expected to launch this year. It is an inhaled product for migraine - SCF processing enables exceptional particle size control and lung deposition resulting in rapid uptake. The particle design and scale-up to GMP for this product were managed by members of the Crystec team.
Cranfield University - Crop Water Use Group Cranfield Bedfordshire MK43 0AL United Kingdom Water is the most important factor limiting crop production on a global scale; water resources are increasingly under pressure due to population growth, climate change, competition from diverse users and the desire to prevent environment damage.
The Crop Water Use Group takes a multidisciplinary approach to improve crop production when water is limiting. Our research projects include the disciplines of plant physiology, molecular biology, molecular genetics, soil water dynamics and irrigation science. Crescendo Biologics Meditrina Building Babraham Research Campus Cambridge CB22 3AT Crescendo Biologics focuses on in vivo generation of human heavy chain antibodies through transgenic mice, developing therapeutic antibodies, and affinity optimization using ribosome display platforms.
Our unique approach allows in a single assay to screen for a broad spectrum of cardiovascular liabilities that include single and multiple ion channel effects, inotropic actions, time dependent effects, complex pharmacology, chronic effects and cardiotoxicity. This allows for early screening of candidate compounds as well as supporting late stage compounds with known cardiac liabilities needing risk assessment.
We support drug development across a broad array of areas including heart failure, vascular biology, neural, oncology, diabetes and metabolism, immunology and infectious diseases. Other services includes sequence verification, intact mass, protein interaction test, aggregation.
Cranfield University - Wolfson Field Laboratory Cranfield Bedfordshire MK43 0AL United Kingdom The laboratory is for measuring whole-soil carbon balances and greenhouse gas fluxes, including stable-isotope compositions, in large, intact, hydrologically-isolated soil monoliths lysimeters under field conditions.
It contains 24 lysimeters connected to automated gas flux chambers and instruments. The lysimeters are 0. Each is equipped with systems for controlling soil moisture and surface temperature, and instruments to allow near continuous sampling of gases emitted from the surface, dissolved solutes passing out of the bottom, and temperature, moisture and soil solution at different depths.
Onsite environmental conditions are monitored with a weather station. The gas flux chambers 26cm head space are fixed over the soil surface and have pneumatically operated lids. Gases accumulated in the head space when the lids are closed are passed through a continuous loop to an infra red gas analyser IRGA and an isotope ratio mass spectrometer IRMS housed in an instrument building.
The soil monoliths in the lysimeters contain electrical heating elements in the surface, capable of maintaining the soil surface at up to 5 o C above ambient temperature. They also have automated sprinkler irrigation systems, delivering rainwater collected from the roof of the instrument building. Presently the system contains two soil types planted with grass. These are a well-drained, acid, coarse loamy soil from Bedfordshire, and a poorly-drained, seasonally waterlogged loamy soil over clay from Warwickshire.
The soil monoliths were taken intact from these sites, preserving the natural soil structure, and brought to Cranfield. The provision of sample containers and custody documentation, sample collection and reporting costs are included in the price of analysis.
Sample collection is mostly provided utilising in-house drivers to ensure timely and safe sample delivery to the laboratory so that samples are received in optimum condition for analysis with traceability from the sample origin. Couriers are sometimes used when this is not practical. Chemtest can provide bespoke reporting formats in several different media according to clients' specifications.
Normal control brain tissue from people without neurological disorders is also available. The facility routinely supplies material to researchers working in Neuroscience, as well as University and Medical Research Council MRC funded research projects.
It is the first international cooperation that seeks to establish a collection of biological samples from tumours and normal tissues from patients for whom the aetiology of their disease is known - exposure to radioiodine in childhood. The project is coordinated from Imperial College, London and works with Institutes in the Russian Federation the Medical Radiological Research Centre in Obninsk and Ukraine the Institute of Endocrinology and Metabolism in Kiev to support local scientists and clinicians to manage and run a tissue bank for those patients who have developed thyroid tumours following exposure to radiation from the Chernobyl accident.
Belarus was also initially included in the project, but is currently suspended for political reasons. Censo provides access to a diverse range of existing human iPSC lines, and ethically sources relevant human tissue, both healthy and with disease specific mutations, with which to custom generate new iPSC lines from large cohorts of individuals.
We can gene edit these lines to knock in, knock out or correct target genes of interest, and have developed reproducible differentiation protocols for a number of lineages, including microglia, astrocytes, cortical, and sensory neurons. Using these cells for neurodegenerative and neuro-inflammatory disease discovery, we offer customisable phenotypic assays to deliver new insights and functional disease related understanding of our clients compounds, Our technology also enables the study of genotype-phenotype relationships in large populations, providing an understanding of patient population therapeutic response variability.
In addition, our Consultancy Group are on hand to assist with projects including laboratory auditing and training and have experience working in many countries around the globe. The company has assembled a technically diverse staff, enabling us to develop and expand our Ecotoxicology services delivering timely reports to an ever-expanding international client base.
In addition, biodegradation and bioaccumulation studies and many other study types are available to fulfil international regulatory requirements. To compliment our toxicology studies Chemex has a comprehensive range of analytical instrumentation and expert analysts to enable confirmation of test substance concentrations throughout studies, where specified. Our GLP compliant facility near Cambridge, UK provides independent laboratory testing of the highest quality and excellent customer service to a diverse range of clients.
In addition, Chemex' multilingual Consultancy Group are able to assist with projects such as, Laboratory Auditing, Staff Training in various aspects of sampling or analysis techniques, off-shore sampling, production of Quality Plans and data review services.
Our team are on hand to assist with projects around the globe. We place a great deal of emphasis on training in order to maintain the highest levels of expertise, efficiency and GLP compliance. CN Bio Innovations Ltd.
We provide products and services to the pharmaceutical industry and in the past 3 years have used our proprietary organ-on-chip models in drug discovery and drug safety programs with more than 25 pharmaceutical companies. CN Bio has also pursued research to develop disease organ-on-chip models with successful programmes resulting in novel models of non-alcoholic steatohepatitis and Hepatitis B virus infection.
Working closely with academic pioneers in the bio-engineering field, and backed by prestigious grant awards from sponsors including DARPA and Innovate UK, CN Bio continues to develop next generation organs-on-chips. Cefas Technology Limited England United Kingdom Cefas Technology Limited CTL is a wholly owned subsidiary of Cefas that specialises in the application of Cefas technology to specific customer needs in a cost effective and focussed manner.
CTL products, services and systems are developed by teams that are experienced in fisheries and environmental management and of working closely with clients to ensure that their needs are fully met. Our technical solutions are offered alongside the wide range of research and consultancy processes and services that Cefas offers.
Cefas is a multidisciplinary scientific research and consultancy centre providing a comprehensive range of services in fisheries management, environmental monitoring and assessment and aquaculture to a large number of worldwide clients.
Cefas has staff and has a long and successful track record in delivering high quality services to clients in a confidential and impartial manner. Cefas has wide experience in delivering reliable, cost effective Information Systems that integrate processes and information across different organisations and locations using the latest Internet based technology to reduce costs and to improve access to data.
Specialised in Oncology and Infectious Diseases therapeutical area but have extensive experience across other different therapeutic areas as well. We are able to support requests from the world's top pharma and biotechs using scientist. Our key services include: 1. Decision Modelling 2. Real-World Evidence and Data Analytics 3. Review and Evidence Synthesis 4. Market Access and Value Communication 5.
Training Why us? Academic rigour with commercial awareness 2. Senior team works on the project materially - unlike other vendors 3. Small and focused team, supports clients hands-on from start to end and beyond of the projects 4. High quality deliverables, cost-effective pricing.
Over , reagents. Capsant Neurotechnologies Romsey, England, SO51 United Kingdom Capsant Neurotechnologies provides in-vitro tissue based screening technologies based on ex-vivo tissues and reaggregated 3D systems. Organoids are a 3D cell structures with organ-like characteristics grown from stem cells. The Company is currently commercializing organoid models that are a powerful new enabling technology in drug discovery and genetics research.
Curo Consulting Chilterns House Dean Street Marlow SL7 3AA UK Curo Consulting provides highly differentiated value communication solutions to the Pharmaceutical sector, enabling our clients to discuss the value and return on investment proposition to their new therapies with budget holders in state and private health services.
Well respected in the industry, we pride ourselves on thinking beyond the usual parameters of the pharma world. True, we have a team of Health Economics experts and specialist software builders, but we are not data processors, nor a software company.
We are the leading importer, distributor and manufacturer of nutritional ingredients, as well as made-to-specification finished products. Specialising in the healthcare, consumer, and industrial equipment sectors, our solutions start at the point a business decides upon the need for innovation and finish with the launch of a breakthrough new product that is customer focused and commercially effective.
We provide market access skills, knowledge and expertise to the pharmaceutical, biotech and device industries. We help our clients to identify, understand and overcome the wide-ranging market access challenges that emerge throughout the life-cycle of their products.
With a strong combination of public sector, industry and consulting experience we are able to deliver genuine insights across multiple stakeholder perspectives ensuring that our clients get both the highest quality research and the know-how to make it count. Tissue samples from the CCLG Tissue Bank gives scientists the chance to get as close to the disease as possible — so they can find new diagnostic methods, treatments and cures for childhood cancers.
ChemQuest Ltd. CXR Biosciences provides preclinical services and expertise, specialising in investigative toxicology, exploratory and discovery toxicology, metabolism and pharmacokinetics. We specialise in custom synthesis and route development to support the life sciences industries.
Highly cost and time competitive. Using the power of flow or batch chemistry, our unique approach puts synthesis, screening and molecular design firmly back together in a single laboratory allowing fast iterative exploration of vast areas of diverse chemical space.
DxS Ltd. DXS has a range of products that enables healthcare stakeholders, such as Primary Care Organisations, Pharmaceuticals, Healthcare Educators, Service Providers and many more to provide pertinent information regarding patient treatment to a busy clinician in the workflow. The result is improved outcomes delivered cost effectively.
We design and produce HPCE instruments which we are marketing worldwide. We also use the same instruments to offer Analytical Services and Contract Research. High Performance Capillary Electrophoresis and Label Free Intrinsic Imaging applied to a CE analytical system offers dramatically improved discovery power in comparison to other conventional CE systems.
Diamond Pharma Services No. Diamond BioPharm Ltd provides consultancy services in European regulatory affairs and product development to the biotech and pharmaceutical industries. The company was founded in under the leadership of Dr. Maureen Graham ex. The team Dr Graham has established includes those with a broad and varied industry experience and former regulators, offering both breadth and depth of expertise, from which our clients can benefit.
Our many years of industry experience and expertise is across a broad range of therapeutic areas and product types biotechnology including monoclonal antibodies, gene-therapy and new chemical entities - both innovative and generics.
The entire team has significant experience and knowledge of European regulatory procedures national, mutual recognition, decentralised and centralised and an in-depth awareness of current legislation and industry trends.
Diamond BioPharm consultants have extensive experience of assisting clients with regulatory support from early stages of product development through to achievement of marketing authorisations, orphan designations, scientific advice and have also assisted with the maintenance of marketing authorisations through variations, and monitoring and updating of prescribing information.
Diamond Pharma Services, Inc. The company was founded in as a subsidiary of Diamond BioPharm Ltd. We are a privately owned company with extensive management experience in the creation and successful operation of innovative manufacturing processes. Dotmatics England United Kingdom Dotmatics offers compound sourcing, analytics, chemical libraries, structure elucidation, and assay reporting.
Past projects include predictive models linking genomic in-vitro data to drug efficacy in real patient cohorts and region-of-interest identification in oncology digital pathology images. Data are used to predict human exposure following contact with the skin.
In addition, we offer a range of custom synthesis and contractual research opportunities to the agrochemical and pharmaceutical industries, biotech and catalogue companies.
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